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Chemical Genomics

Chemical Genomics PDF Author: Edward D. Zanders
Publisher: Springer Science & Business Media
ISBN: 1592599486
Category : Science
Languages : en
Pages : 280

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Book Description
Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations. Academic scientists have been exploring the functions of proteins using small molecules as probes for many years and therefore would also b- efit from sharing ideas and laboratory procedures. Whatever the organizational backgrounds of the scientists involved, the challenges of extracting the ma- mum human benefit from genome sequencing projects remains considerable, and one where it is increasingly recognized that chemical genomics will play an important part. Chemical Genomics: Reviews and Protocols is divided into two sections, the first being a series of reviews to describe what chemical genomics is about and to set the scene for the protocol chapters. The subject is introduced by Paul Caron, who explains the various flavors of chemical genomics. This is f- lowed by Lutz Weber and Philip Dean who cover the interaction between organic molecules and protein targets from the different perspectives of la- ratory experimentation and in silico design. The protocols begin with the me- ods developed in Christopher Lowes’ laboratory (Roque et al.

Chemical Genomics

Chemical Genomics PDF Author: Edward D. Zanders
Publisher: Springer Science & Business Media
ISBN: 1592599486
Category : Science
Languages : en
Pages : 280

View

Book Description
Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations. Academic scientists have been exploring the functions of proteins using small molecules as probes for many years and therefore would also b- efit from sharing ideas and laboratory procedures. Whatever the organizational backgrounds of the scientists involved, the challenges of extracting the ma- mum human benefit from genome sequencing projects remains considerable, and one where it is increasingly recognized that chemical genomics will play an important part. Chemical Genomics: Reviews and Protocols is divided into two sections, the first being a series of reviews to describe what chemical genomics is about and to set the scene for the protocol chapters. The subject is introduced by Paul Caron, who explains the various flavors of chemical genomics. This is f- lowed by Lutz Weber and Philip Dean who cover the interaction between organic molecules and protein targets from the different perspectives of la- ratory experimentation and in silico design. The protocols begin with the me- ods developed in Christopher Lowes’ laboratory (Roque et al.

Chemical Genomics

Chemical Genomics PDF Author: Haian Fu
Publisher: Cambridge University Press
ISBN: 0521889480
Category : Medical
Languages : en
Pages : 345

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Book Description
This text covers new techniques and applications in chemical genomics for researchers, professionals and graduates in biology, biomedicine and chemistry.

Chemical Genomics

Chemical Genomics PDF Author: Ferenc Darvas
Publisher: CRC Press
ISBN: 9780824754907
Category : Science
Languages : en
Pages : 376

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Book Description
This interdisciplinary reference identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology. The book tracks the emergence of a large variety of novel techniques such as the small-molecule drugability of new targets, the generation and synthesis of small-molecule libraries, and the determination of targets and mechanisms by genomic profiling and guides readers in the selection of the most appropriate technology for their specific dilemma by highlighting procedures utilized in other scientific disciplines.

Chemical Genomics

Chemical Genomics PDF Author: Stefan Jaroch
Publisher: Springer Science & Business Media
ISBN: 3540376356
Category : Science
Languages : en
Pages : 179

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Book Description
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Chemical Genomics and Proteomics

Chemical Genomics and Proteomics PDF Author: Ferenc Darvas
Publisher: CRC Press
ISBN: 1439830592
Category : Medical
Languages : en
Pages : 243

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Book Description
Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplina

Chemical Genomics Analysis of TFIIH Kinase Function in Saccharomyces Cerevisiae

Chemical Genomics Analysis of TFIIH Kinase Function in Saccharomyces Cerevisiae PDF Author: Elenita Ilieva Kanin
Publisher:
ISBN:
Category :
Languages : en
Pages : 195

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Chemical Genomics and Proteomics

Chemical Genomics and Proteomics PDF Author:
Publisher: Springer
ISBN: 9781617793509
Category :
Languages : en
Pages : 256

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Chemical Genomics and Proteomics

Chemical Genomics and Proteomics PDF Author: Siegfried Neumann
Publisher: Wiley-Blackwell
ISBN: 9783527314720
Category : Science
Languages : en
Pages : 400

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Book Description
Genomic research has provided access to a large number of gene products. New approaches to functional genome and proteome analysis using small molecule tools (= chemical genomics) have become essential for modern drug discovery research as well as for basic biomedical research. Interrogating the genome by chemical genomics is a challenging task that requires the discovery of new techniques and their implementation in a robust format. As a relatively new field of research, chemical genomics will rapidly expand in influence. This book presents modern results of the combined research efforts from synthetic organic chemistry and molecular biology for drug discovery.

Protein Targeting with Small Molecules

Protein Targeting with Small Molecules PDF Author: Hiroyuki Osada
Publisher: John Wiley & Sons
ISBN: 9780470495001
Category : Science
Languages : en
Pages : 312

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Book Description
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications: Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules

A Chemical Genomics Approach to Study Signaling Cascades in Arabidopsis Thaliana

A Chemical Genomics Approach to Study Signaling Cascades in Arabidopsis Thaliana PDF Author: William Blake Hannah
Publisher:
ISBN:
Category :
Languages : en
Pages : 48

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Book Description